There are two ways to wire single-key PCBs:
Between these I've found #2 to be neater and faster, so I recommend you wire Plum Twists with it. That's what I'll cover from here on out.
For wiring you'll need wire, wire strippers, a knife and a self-healing mat to cut on. The knife is handy for cleaning up the 3D print and stripping wire, and the self-healing mat is a great cutting surface and you can use it to keep your work table clean when soldering too. Your local art supply store will surely have both of these, and you should go buy from them and support them! You can also easily find them online.
You'll also of course need a soldering iron and solder. Something affordable like the Pinecil or TS100 will do the job just fine, and because of the large row and column pads, you can use a large tip like the BC2 tip the Pinecil comes with.
I recommend solid 26-30 gauge wire. Solid means there's only one conductor inside. Some flexible wires are stranded and have many twisted conductors inside (much like braided hair), which make the end of the wire harder to solder. I recommend buying a pack of multiple colors of insulated wire. You'll need insulated wire to solder the rows, but you could substitute uninsulated wire for the columns. Nevertheless, the insulated wire is safer as there's no chance of accidentally shorting something.
I include a large paperclip in all Plum Twist orders I receive online. I highly recommend you use it for twisting in the PCB! Fully unbend the paperclip so it becomes a straight line, then fold it exactly in half. You can then stick the 2 ends of the paperclip into the 2 small holes on the PCB's centerline to get a better grip when twisting.
If you have a 3D printer, you can make the process even easier for yourself. I've designed a 3D model that keeps your paperclip ends aligned and makes the jig easier to grip. It should take about 30 minutes to print and doesn't need supports.
If you take one thing away from this next paragraph, remember: chain the inputs and outputs (I's and O's). Collect the powers and grounds (+'s and -'s).
Every LED must have its Ground (-) pin connected to one of the ground pins on the microcontroller. The Power Pins (+) should be run to the 5V/VUSB pin on microcontrollers with 5V logic (e.g. ATmega32U4-based ones), whereas it should be run to the 3.3V pin on microcontrollers with 3.3V logic (e.g. RP2040). It is techically against the spec to supply these LEDs with only 3.3V, but I have seen this work well enough to feel comfortable recommending you do so. The alternative is to power the LEDs from 5V but stick a “sacrificial LED” in between the first PCB and your 3.3V microcontroller to boost the signal voltages.
To go about soldering every PCB's + and - pins to 2 single pins on the microcontroller, I suggest you use a "tree branch" approach. Cut 6 or so wires to about 3in / 8cm, strip both ends, and solder these wires to + pins of a cluster of neighboring PCBs. Then twist together all the loose ends. Repeat this process for the rest of the PCBs, so that you have about 6 bundles of 6 wires. Now cut more wires and solder a wire to the end of every bundle. Finally, twist these wires together and connect them to microcontroller pin. Repeat this process for the - pins. If you have thicker wires, you may find creating bundles of 4 and doing 3 rounds of bundling/twisting/soldering to be easier. If you like being neat, you can bundle together the columns first, then connect together all the column power pins.
If you have a programming or math background, you may appreciate that with a branching factor of k, the number of solder joints per PCB for say the + pins is at most k/(k-1) for a full tree. Compare that to a factor of 2 for the conventional wiring used on Amoeba PCBs. It may look unconventional but it saves you time!
For the Input (I) and Output (O) connections, the Input of the PCB nearest to the microcontroller should connect to a microcontroller pin. After that, connect all PCBs in a chain (a zigzap pattern is easiest) so that the Output of every PCB connects to the Input of the next. The final PCB should have its Output (O) not connected to anything.
You can find design files for the PCB over at the Cosmos Keyboard PCBs repository.